![]() ![]() ![]() All these salts exhibit greater solubility in hot water than cold, allowing for easy recrystallization. In general, the water solubility of uric acid and its alkali metal and alkaline earth salts is rather low. Uric acid is a diprotic acid with p K a1 = 5.4 and p K a2 = 10.3, thus at physiological pH, it predominately exists as the monoionic urate ion. Although the lactim form is expected to possess some degree of aromaticity, uric acid crystallizes in the lactam form, with computational chemistry also indicating that tautomer to be the most stable. Uric acid displays lactam–lactim tautomerism (also often described as keto–enol tautomerism ). ![]() In 1882, the Ukrainian chemist Ivan Horbaczewski first synthesized uric acid by melting urea with glycine. Uric acid was first isolated from kidney stones in 1776 by Swedish chemist Carl Wilhelm Scheele. High blood concentrations of uric acid can lead to gout and are associated with other medical conditions, including diabetes and the formation of ammonium acid urate kidney stones. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Langmans-medical-embryology-12th-ed pdf Lippincott Illustrated Reviews Pharmacology 6th edition pdf Harsh Mohan - Pathology Practical Book, 2nd Editionpdf 147Physiology 5th Ed 2011ganong-pdf Textbook of Medical Physiology pdf harpers-illustrated-biochemistry-28th-edition pdf Clinical-Microbiology-Made-Ridiculously-Simple pdf lippincott.Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5H 4N 4O 3.They are one of the best selling books in medical industry are are well know from their books. Lippincott Illustrated Reviews Physiology pdf Review: This illusted reviews physiology is published by lippinocott series which is one of the most well known publishers of medical books.The project began with a simple idea: to create a concise yet comprehensive microbiology review tool. We are very pleased to present the fourth edition of Lippincott’s Microcards, a product designed for medical students to learn and review clinical microbiology. ![]()
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